Research Funding

Title: Lysophosphatidic acid (LPA) signaling in CNS myelin repair
Major Goals: 
Name of PD/PI: Babette Fuss, PhD (PI),

Name of co-investigators: Yan Zang, PhD, Jeffrey Dupree, PhD, Unsong Oh, MD
Source of Support: National Multiple Sclerosis Society
Project Start/End Dates: 04/2025 -  
Total Award Amount: 

Title: Lysophosphatidic acid (LPA) signaling in CNS myelination and myelin repair
Major Goals: 
Name of PD/PI: Babette Fuss, PhD (PI),

Name of co-investigators: Greg Walsh, PhD, Yan Zang, PhD, Unsong Oh, MD
Source of Support: VCU 
Project Start/End Dates: 07/2024 - 06/2026
Total Award Amount: $200,000

Title: Nociceptin role in the progression of multiple sclerosis
Major Goals: 
Name of PD/PI: Carmen Sato-Bigbee, PhD (PI),

Name of co-investigators: Myla Goldman, MD, Unsong Oh, MD 
Source of Support: National Multiple Sclerosis Society
Project Start/End Dates: 04/2023 - 03/2026
Total Award Amount: $600,000

Title: Validation of a Clinical Outcome Measure of Demyelination: Physiologic, MRI, and Biomarker correlates of 6MW gait speed trajectory

Major Goals:

Name of PD/PI: Myla Goldman, MD

Name of co-investigators: Shanshan Chen, PhD, Unsong Oh, MD

Source of Support: National Multiple Sclerosis Society

Project Start/End Dates: 

Total Award Amount: 

Title: GLT-1/EAAT2: A Novel Player in Myelin Repair
Major Goals: Test the hypothesis that loss of signaling via OLG-expressed GLT-1/EAAT2 impairs myelin regeneration under inflammatory demyelinating conditions The research project’s specific aims are to characterize the role of OLG-derived GLT-1 in modulating remyelination in the chronic cuprizone and the cuprizone/experimental autoimmune encephalomyelitis (EAE) models.
Name of PD/PI: Babette Fuss, PhD (PI),

Name of co-investigators: Unsong Oh, MD 
Source of Support: Department of Defense CDMRP
Project Start/End Dates: 10/1/2022 - 9/30/2024
Total Award Amount: $150,000

Title: The role of LPA6 receptor signaling in myelin repair. 
Major Goals: Test remyelinating potential of inducible conditional Lpa6 knockout in the cuprizone and the cuprizon/EAE model of demyelination. 
Name of PD/PI: Babette Fuss, PhD (PI),

Name of co-investigators: Unsong Oh, MD 
Source of Support: Commonwealth Health Research Board
Project/Proposal Start and End Date: 7/1/2021 - 6/30/2023
Total Award Amount (including Indirect Costs): $200,000